Since you didn't provide any data, I've created some here.
users <- data.frame(username = c('rod','stewart','happy'), col1 = c(NA_character_,'do','run'), col2 = c(111,23,145), stringsAsFactors = FALSE)
To update using base R:
users[users$username == 'rod', c('col1','col2')] <- c('setup', 232)
If you prefer the more explicit syntax provided by the data.table package, you would execute:
library(data.table)
setDT(users)
users[username == 'rod', `:=`(col1 = 'setup', col2 = 232)]
To update your database through RPostgreSQL, you will first need to create Database Connection, and then simply store your query in a string, e.g.
con <- dbConnect('PostgreSQL', dbname = <your database name>, user=<user>, password= <password>)
statement <- "update <schema>.users set col1='setup', col2= 232 where username='rod';"
dbGetQuery(con, statement)
dbDisconnect()
Note depending upon your PostgreSQL configs, you may need to also set your search path dbGetQuery(con, 'set search_path = <schema>;')
I'm more familiar with RPostgres, so you may want to double check the syntax and vignettes of the PostgreSQL package.
EDIT: Seems like RPostgreSQL prefers dbGetQuery to send updates and commands rather than dbSendQuery