If you're using Python 3, it's pretty easy. First, convert the str to bytes in a chosen encoding (utf-8 is usually appropriate), then use int.from_bytes to convert to an int:
number = int.from_bytes(mystring.encode('utf-8'), 'little')
Converting back is slightly trickier (and will lose trailing NUL bytes unless you've stored how long the resulting string should be somewhere else; if you switch to 'big' endianness, you lose leading NUL bytes instead of trailing):
recoveredstring = number.to_bytes((number.bit_length() + 7) // 8, 'little').decode('utf-8')
You can do something similar in Python 2, but it's less efficient/direct:
import binascii
number = int(binascii.hexlify(mystring.encode('utf-8')), 16)
hx = '%x' % number
hx = hx.zfill(len(hx) + (len(hx) & 1)) # Make even length hex nibbles
recoveredstring = binascii.unhexlify(hx).decode('utf-8')
That's equivalent to the 'big' endian approach in Python 3; reversing the intermediate bytes as you go in each direction would get the 'little' effect.